Anthralin Inhibition of Mouse Epidermal Arachidonic Acid Lipoxygenase In Vitro
نویسندگان
چکیده
منابع مشابه
Anthralin derivatives--inhibition of 5-lipoxygenase--antipsoriatic efficacy.
Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no corre...
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The retinoids all-trans-retinoic acid, 13-cis-retinoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1E- propen-1-yl]benzoic acid, 6-[1-(4-carboxyphenyl)-1E-propen-2-yl]-3,4-dihydro-4,4-dimethyl-2H -1-benzothiopyran, and 6-(5,6,7,8,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)- 2-naphthalenecarboxylic acid inhibited the induction of ornithine decarboxylase in CD-1 mouse ...
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Arachidonic acid (AA) metabolites function as EDHFs in arteries of many species. They mediate cyclooxygenase (COX)- and nitric oxide (NO)-independent relaxations to acetylcholine (ACh). However, the role of AA metabolites as relaxing factors in mouse arteries remains incompletely defined. ACh caused concentration-dependent relaxations of the mouse thoracic and abdominal aorta and carotid, femor...
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39 Arachidonic acid (AA) metabolites function as endothelium-derived hyperpolarizing 40 factors (EDHFs) in arteries of many species. They mediate cyclooxygenase (COX)and nitric 41 oxide (NO)-independent relaxations to acetylcholine. However, the role of AA metabolites as 42 relaxing factors in mouse arteries remains incompletely defined. Acetylcholine caused 43 concentration-dependent relaxatio...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1983
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12523249